S7
About this Product
- SKU:
- CY-020
- Additional Names:
- Peptide L, pepL, S7 peptide|S7, pepL, LSLITRL, CY-020, CY020
- Extra Details:
- S7 is a peptide identified from a phage display library, which selectively binds to the interleukin-6 receptor (IL-6R) alpha chain (gp80) and inhibits IL-6 mediated events. S7 can inhibit IL-6 induced VEGF-A expression and angiogenesis in different cancer cell lines, and can prevent IL-6 mediated survival signalling and sensitise cervical cancer cells to chemotherapy. S7 is bioavailable in vivo, and can induce apoptopic cell death and suppress IL-6 induced tumour growth in mouse models.
- Immunogen:
- Cytokine receptors
- Molecular Weight:
- 815.02
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Su et al (2005) A novel peptide specifically binding to interleukin-6 receptor (gp80) inhibits angiogenesis and tumor growth. Cancer Res. 65(11) 4827 <a href="https://pubmed.ncbi.nlm.nih.gov/15930303/" target="_blank">PMID: 15930303</a></p><p>Figueiredo et al (2020) Ligand-Mediated Targeting of Cytokine Interleukin-27 Enhances Its Bioactivity In Vivo. Mol. Ther. Methods Clin. Dev. <strong>17</strong> 739 <a href="https://pubmed.ncbi.nlm.nih.gov/32346551/" target="_blank">PMID: 32346551</a></p><p>Figueiredo et al (2021) Reengineering Tumor Microenvironment with Sequential Interleukin Delivery. Bioengineering <strong>8</strong>(7) 90 <a href="https://pubmed.ncbi.nlm.nih.gov/34209203/" target="_blank">PMID: 34209203</a><br></p>
- Sequence:
- H-Leu-Ser-Leu-Ile-Thr-Arg-Leu-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C37H70N10O10
