S1H
About this Product
- SKU:
- CY-010
- Additional Names:
- S1H (36-51)|S1H, Ac-YIPKEQKYSFLQNPQT-NH2, CY-010, CY010
- Extra Details:
- S1H is a 16-residue peptide designed as a direct sequence mimetic of the site 1 mini-helix (residues 36-51) of wild-type human growth hormone (hGH). S1H acts as an inhibitor by blocking the interaction of hGH with the human growth hormone receptor (hGHR). S1H mitigates phosphorylation of STAT5 in cells co-treated with hGH, reducing intracellular STAT5 phosphorylation levels to those of untreated controls. S1H can be used as a chemical tool to study the molecular nature of hGH-hGHR interactions.
- Immunogen:
- Cytokine receptors
- Molecular Weight:
- 2025.29
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Basu et al (2021) A novel peptide antagonist of the human growth hormone receptor. J Biol Chem. 296 100588 <a href="https://pubmed.ncbi.nlm.nih.gov/33774052/" target="_blank" rel="nofollow">PMID: 33774052</a>
- Sequence:
- Ac-Tyr-Ile-Pro-Lys-Glu-Gln-Lys-Tyr-Ser-Phe-Leu-Gln-Asn-Pro-Gln-Thr-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C94H141N23O27
