Nelfinavir mesylate
Product Sizes
10 mg
£95.00
CV-040-10MG
About this Product
- SKU:
- CV-040
- Additional Names:
- AG 1343|Nelfinavir, AG 1343, human immunodeficiency virus, HIV, protease inhibitor, anticancer, apoptosis, Akt/PKB signaling pathway, SARS, MERS-CoV, 159989-65-8, CV-040, CV040
- CAS Number:
- 159989-65-8
- Extra Details:
- Nelfinavir, also known as AG 1343, is a potent human immunodeficiency virus (HIV)-1 protease inhibitor with a Ki of 2 nM in vitro. Nelfinavir also displays broad spectrum anticancer activity and can inhibit the growth of cancer cells and trigger apoptosis. Nelfinavir has two main mechanisms of cancer cell growth inhibition, inhibition of the Akt/PKB signaling pathway and activation of endoplasmic reticulum stress with subsequent unfolded protein response. Nelfinavir also displays efficacy against malaria, tuberculosis and SARS and exhibits anti-MERS-CoV activity in vero cells in vitro.
- Immunogen:
- Kinases,Other proteases,Antivirals
- Molecular Weight:
- 663.9
- Physical State:
- Lyophilized
- Purity:
- >98% by hplc; NMR conforms to structure
- References:
- <p>Patick et al (1996) Antiviral and resistance studies of AG1343, an orally bioavailable inhibitor of human immunodeficiency virus protease. Antimicrob.Agents Chemother. <strong>40</strong> 29 PMID: 8787874 </p><p>Gills et al (2007) Nelfinavir, a lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy and apoptosis in vitro and in vivo. Clin.Cancer Res. <strong>13</strong> 5183 </p><p>Ko et al (2020) Screening of FDA-approved drugs using a MERS-CoV clinical isolate from South Korea identifies potential therapeutic options for COVID-19. BioRxiv 2020.02.25.965582; doi: https://doi.org/10.1101/2020.02.25.965582</p>
- Sequence:
- (3S,4aS,8aS)-N-(1,1-Dimethylethyl)decahydro-2-[(2R,3R)-2-hydroxy-3-[(3-hydroxy- 2-methylbenzoyl)amino]-4-(phenylthio)butyl]-3-isoquinolinecarboxamide methanesulfonate
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dessicated, frozen and in the dark
- Size:
- 10 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble in DMSO to 70mg/ml
- Formula:
- C32H45N3O4S. CH3SO3H
