Camostat mesylate
Product Sizes
10 mg
£59.00
CV-001-10MG
About this Product
- SKU:
- CV-001
- Additional Names:
- Camostat, serine protease inhibitor, plasmin, kallikrein, thrombin, trypsin, TMPRSS2, SARS-CoV , 59721-29-8, CV-001, CV001
- CAS Number:
- 59721-29-8
- Extra Details:
- Camostat is an orally active serine protease inhibitor which can inhibit plasmin, kallikrein, thrombin and trypsin, and attenuate pancreatic fibrosis in vivo. Camostat also inhibits influenza virus replication in human tracheal epithelial cells and reduces infection of Calu-3 lung cells by SARS-CoV-2 through inhibition of the serine protease TMPRSS2, required for viral spike protein priming. In mice, camostat was effective in protecting against death following a lethal SARS-CoV infection, with a survival rate of 60%.
- Immunogen:
- Serine proteases
- Molecular Weight:
- 494.5
- Physical State:
- Lyophilized
- Purity:
- >98%
- References:
- <p>Ishikura et al (2007) The proteinase inhibitor camostat mesilate suppresses pancreatic pain in rodents. Life Sci. <strong>80</strong> 1999 <a href="https://pubmed.ncbi.nlm.nih.gov/17433371/" target="_blank" rel="nofollow">PMID: 17433371</a></p><p>Hoffmann et al (2020) SARS-CoV-2 cell entry depends on ACE2 and TMPRSS2 and is blocked by a clinically-proven protease inhibitor. Cell <strong>181</strong> 271 <a href="https://pubmed.ncbi.nlm.nih.gov/32142651/" target="_blank" rel="nofollow">PMID: 32142651</a></p><p>Uno (2020) Camostat mesilate therapy for COVID-19. Intern. Emerg. Med. Apr 29 1 doi: 10.1007/s11739-020-02345-9. Epub ahead of print. <a href="https://pubmed.ncbi.nlm.nih.gov/32347443/" target="_blank" rel="nofollow">PMID: 32347443</a></p>
- Sequence:
- 4-2-2-dimethylamino-2-oxoethoxy-2-oxoethylphenyl 4-guanidinobenzoate, methanesulfonic acid salt
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 10 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Small Molecules
- Solubility:
- Soluble in water and DMSO to 50mg/ml
- Formula:
- C20H22N4O5 CH3SO3H
