Apelin 12
About this Product
- SKU:
- CS-020
- Additional Names:
- A12
- CAS Number:
- 229961-08-4
- Extra Details:
- Apelin 12 (A12) is a biologically active C-terminal fragment of the 77 amino acid prepropeptide apelin, which is also the precursor of apelin 13 and apelin 36. Apelin 12 lowers blood pressure via a nitric oxide-dependent mechanism and is involved in control of feeding through stimulation of cholecystokinin (CCK) secretion. Apelin 12 can also reduce infarct size (IS) and augment contractile function recovery in the heart of rodents after regional or global ischemia.
- Molecular Weight:
- 1422.7
- Purity:
- >95% by HPLC
- References:
- <p>Tatemoto et al (1998) Isolation and Characterization of a Novel Endogenous Peptide Ligand for the Human APJ Receptor. Biochem. Biophys. Res. Commun. <strong>251</strong> (2) 471 <a href="https://pubmed.ncbi.nlm.nih.gov/9792798/" target="_blank" rel="nofollow">PMID: 9792798</a></p><p>Pisarenko et al (2011) In vivo reduction of injury to the heart with apelin-12 peptide in rats. Bull. Exp. Biol. Med. <strong>152</strong>(1) 79 <a href="https://pubmed.ncbi.nlm.nih.gov/22803046/" target="_blank" rel="nofollow">PMID: 22803046</a></p><p>Pisarenko et al (2013) Effects of structural analogues of apelin-12 in acute myocardial infarction in rats. J. Pharmacol. Pharmacother. <strong>4</strong>(3) 198 <a href="https://pubmed.ncbi.nlm.nih.gov/23960425/" target="_blank" rel="nofollow">PMID: 23960425</a></p>
- Sequence:
- H-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dessicated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in physiological buffers including PBS (>1mg./mL). Soluble in DMSO as a stock solution.
- Formula:
- C64H103N21O14S