Z-DEVD-FMK
About this Product
- SKU:
- CS-010
- Additional Names:
- Z-DEVD-fluoromethyl ketone, z-DEVD.fmk|Z-DEVD-FMK, Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone, DEVD, Z-DEVD-fluoromethyl ketone, 210344-95-9, CS-010
- CAS Number:
- 210344-95-9
- Extra Details:
- Z-DEVD-FMK is a cell-permeable, irreversible inhibitor of caspase-3 with an IC50 of 0.13 uM and no activity at cathepsin B and cathepsin L. Z-DEVD-FMK inhibits apoptotic cell death in many cell types including cancer cells, it is neuroprotective in rat hippocampus following seizures in vivo and local application of Z-DEVD-FMK after spinal cord injury in rats reduces secondary tissue injury and helps preserve motor function.
- Immunogen:
- Caspases
- Molecular Weight:
- 668.67
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Ma et al (1998) Synergistic effects of caspase inhibitors and MK-801 in brain injury after transient focal cerebral ischaemia in mice. Br J Pharmacol. 124(4) 756 <a href="https://pubmed.ncbi.nlm.nih.gov/9690868/" target="_blank" rel="nofollow">PMID: 9690868</a><br></p><p>Henshall et al (2000) Involvement of caspase-3-like protease in the mechanism of cell death following focally evoked limbic seizures. J.Neurochem.<strong> 74</strong> 1215 <a href="https://pubmed.ncbi.nlm.nih.gov/10693954/" target="_blank">PMID: 10693954</a></p><p>Barut et al (2005) The neuroprotective effects of z-DEVD.fmk, a caspase-3 inhibitor, on traumatic spinal cord injury in rats. Surg Neurol. <strong>64</strong>(3) 213 <a href="https://pubmed.ncbi.nlm.nih.gov/16099247/" target="_blank" rel="nofollow">PMID: 16099247</a></p>
- Sequence:
- Benzyloxycarbonyl-Asp(OMe)-Glu(OMe)-Val-Asp(OMe)-fluoromethylketone
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in DMSO
- Formula:
- C30H41FN4O12
