A Alpha-helical CRF (9-41)
About this Product
- SKU:
- CR-010
- Additional Names:
- A Alpha-helical CRF 9-41, A Alpha-helical CRF (9-41), 90880-23-2, AHCRF, DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA-NH2, DLTFHLLREMLEMAKAEQEAEQAALNRLLLEEA|A Alpha-helical-Corticotropin-Releasing Factor 9-41, AHCRF, ah-CRF(9-41)
- CAS Number:
- 90880-23-2
- Extra Details:
- A Alpha-helical CRF (9-41) is a corticotropin releasing factor receptor (CRF) antagonist with Ki values of 17, 5 and 0.97 nM at human CRF1, rat CRF2A Alpha and mouse CRF2B Beta receptors respectively. A Alpha-helical CRF (9-41) decreases anxiety like behaviour in the conditioned fear test and reverses the potentiation of startle amplitude produced by administration of CRF in anxiety models. A Alpha-helical CRF (9-41) pre-treatment blocks CRF induced food intake inhibition.
- Immunogen:
- Corticotropin releasing factor receptors
- Molecular Weight:
- 3827
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Swerdlow et al (1989) Potentiation of acoustic startle by corticotropin-releasing factor (CRF) and by fear are both reversed by α-helical CRF (9-41). Neuropsychopharmacology <strong>2</strong> 285 PMID: 2610824</p><p>Skórzewska et al (2009). The effect of CRF and α-helical CRF(9-41) on rat fear responses and amino acids release in the central nucleus of the amygdala. Neuropharmacology <strong>57</strong>(2) 0-156. doi:10.1016/j.neuropharm.2009.04.016</p><p>Smedh et al (2019) Pretreatment with a CRF antagonist amplifies feeding inhibition induced by fourth ventricular cocaine- and amphetamine-regulated transcript peptide. BMC Neurosci<strong> 20</strong> 11 https://doi.org/10.1186/s12868-019-0494-8 <br></p>
- Sequence:
- H-Asp-Leu-Thr-Phe-His-Leu-Leu-Arg-Glu-Met-Leu-Glu-Met-Ala-Lys-Ala-Glu-Gln-Glu-Ala-Glu-Gln-Ala-Ala-Leu-Asn-Arg-Leu-Leu-Leu-Glu-Glu-Ala-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in 0.1% TFA
- Formula:
- C166H274N46O53S2
