Penetratin
About this Product
- SKU:
- CP-040
- Additional Names:
- Antennapedia peptide, Antennapedia (43-58)|Penetratin, Antennapedia peptide, RQIKIWFQNRRMKWKK, Antennapedia (43-58), 188842-14-0
- CAS Number:
- 188842-14-0
- Extra Details:
- Penetratin is a 16-mer peptide derived from the third helix of the Drosophila Antennapedia DNA binding domain that is mapped to be responsible for cellular internalization. Penetratin is able to translocate through the plasma membrane to the cytosol and nucleus, and can facilitate internalization of macromolecular cargoes into living cells, usually by the formation of a conjugate or fusion protein. Penetratin is commonly used as an alternative or complement to Tat peptide for enhancing the cellular uptake of nanoparticles.
- Molecular Weight:
- 2246.8
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Pietersz and Apostolopoulos (2001) A 16-mer peptide (RQIKIWFQNRRMKWKK) from antennapedia preferentially targets the Class I pathway. Vaccine <strong>19</strong>(11-12) 1397 doi: 10.1016/s0264-410x(00)00373-x</p><p>Dupont et al (2011) Penetratin story: an overview. Methods Mol Biol.<strong> 683</strong> 21-9 doi: 10.1007/978-1-60761-919-2_2. PMID: 21053119</p><p>Patel et al (2019) Cell-penetrating peptide sequence and modification dependent uptake and subcellular distribution of green florescent protein in different cell lines. Sci Rep <strong>9</strong> 6298 https://doi.org/10.1038/s41598-019-42456-8<br></p>
- Sequence:
- H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C104H168N34O20S
