Transportan
About this Product
- SKU:
- CP-030
- Additional Names:
- [Lys13]galparan|Transportan, GWTLNSAGYLLGKINLKALAALAKKIL, [Lys13]galparan
- Extra Details:
- Transportan is a 27 amino acid chimeric peptide consisting of 12 amino acids from the amino terminal of galanin and the 14 amino acid peptide mastoparan connected via a lysine residue. Transportan possesses characteristics of both galanin and mastoparan as it inhibits the binding of galanin to the GALR-1 receptor as well as modulating the activity of G proteins through inhibition of GTPase. Transportan is a cell-penetrating peptide which can penetrate into many cell types in a rapid and efficient way. In the cell interior, Transportan localizes mostly in membranous structures and is conveyed into the nuclei, where it concentrates in the nucleoli.
- Immunogen:
- Galanin receptors
- Molecular Weight:
- 2841.47
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Pooga et al (1998) Cell penetration by transportan. FASEB J. <strong>12</strong>(1) 67 doi: 10.1096/fasebj.12.1.67</p><p>Pooga et al (2001), Cellular translocation of proteins by transportan. FASEB J. <strong>5</strong> 1451 https://doi.org/10.1096/fj.00-0780fje<br></p><p>Aguiar etal (2019) Coupling the cell-penetrating peptides transportan and transportan 10 to primaquine enhances its activity against liver-stage malaria parasites. Med. Chem. Commun. <strong>10</strong> 221 https://doi.org/10.1039/C8MD00447A</p>
- Sequence:
- H-Gly-Trp-Thr-Leu-Asn-Ser-Ala-Gly-Tyr-Leu-Leu-Gly-Lys-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C134H226N34O33
