TAT 2-4
About this Product
- SKU:
- CP-020
- Additional Names:
- TAT 2-4, YGRKKRRQRRRGYGRKKRRQRRRG, Transactivator of transcription peptide (2-4), CP-020, CP020|Transactivator of transcription peptide (2-4)
- Extra Details:
- TAT 2-4 is a cell-penetrating peptide, a dimer of the protein transduction domain (47-58) of HIV-tat protein. The TAT peptide (GRKKRRQRRRPQ) is derived from the transactivator of transcription (TAT) of human immunodeficiency virus and acts as a cell-penetrating peptide. The TAT 2-4 peptide sequence (YGRKKRRQRRRGYGRKKRRQRRRG) represents two back-to-back protein transduction (cell-penetrating) domains of TAT. Transactivator of transcription (TAT) protein is produced by HIV-1 and is involved in the induction of HIV-associated neurologic disorders.
- Immunogen:
- Antivirals
- Molecular Weight:
- 3215.78
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Lu et al(2011) HIV-1 Tat-induced microgliosis and synaptic damage via interactions between peripheral and central myeloid cells. PLoS One <strong>6</strong>(9) e23915. doi: 10.1371/journal.pone.0023915</p><p>Hargus and Thayer (2013) Human immunodeficiency virus-1 Tat protein increases the number of inhibitory synapses between hippocampal neurons in culture. J Neurosci. <strong>33</strong>(45) 17908 PMID: 24198379</p><p>Zou et al (2017) Progress in Research and Application of HIV-1 TAT-Derived Cell-Penetrating Peptide. J Membr Biol. <strong>250</strong>(2) 115 doi: 10.1007/s00232-016-9940-z</p>
- Sequence:
- H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C132H240N66O29
