Tat (48-60)
About this Product
- SKU:
- CP-010
- Additional Names:
- HIV-1 Tat (48 - 60)|Tat (48-60), HIV-1 Tat (48 - 60), cell penetrating, cationic peptide, N-terminus of the Tat protein, CP-010, CP010
- Extra Details:
- Tat (48 - 60), also known as HIV-1 Tat (48 - 60), is a cell penetrating cationic peptide derived from the N-terminus of the Tat protein, which is a transactivator of the transcription protein present in the human immunodeficiency virus (HIV). Tat (48-60) is an arginine-rich basic peptide which has three domains that function to aid HIV through transactivation, DNA binding and nuclear transport. Tat (48-60) posseses antibacterial activity but is mainly used for the non disruptive transport of exogenous macromolecules into cells.
- Immunogen:
- Antibacterials
- Molecular Weight:
- 1719
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Futaki (2005) Membrane-permeable arginine-rich peptides and the translocation mechanisms. Adv. Drug Deliv Rev. <strong>57</strong>(4) 547 PMID: 15722163 </p><p>Dennison et al (2007) Interactions of cell penetrating peptide Tat with model membranes: A biophysical study. Biochem. Biophys. Res. Commun. <strong>363</strong>(1) 178 https://doi.org/10.1016/j.bbrc.2007.08.162</p><p>Zhu and Shin (2009) Effects of dimerization of the cell-penetrating peptide Tat analog on antimicrobial activity and mechanism of bactericidal action. J. Pept. Sci. 2009 <strong>15</strong>(5) 345-52 doi: 10.1002/psc.1120. PMID: 19206074</p>
- Sequence:
- H-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Pro-Pro-Gln-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water and physiological buffers
- Formula:
- C70H131N35O16
