EPI-X4
About this Product
- SKU:
- CK-030
- Additional Names:
- Endogenous peptide inhibitor of CXCR4, hSA(408-423) peptide
- Extra Details:
- EPI-X4 (endogenous peptide inhibitor of CXCR4) is a fragment identified from a blood-derived peptide library, corresponding to residues 408-423 of human serum albumin (hSA). EPI-X4 is a highly specific endogenous CXCR4 antagonist which is evolutionarily conserved and generated from the albumin precursor by pH-regulated proteases under acidic conditions that are a hallmark of inflammation. EPI-X4 suppresses CXCR4 signaling and inhibits infection by CXCR4 tropic HIV-1 strains. EPI-X4 can also antagonize CXCL12-induced tumour cell migration, mobilise stem cells and suppress inflammatory responses in mice. EPI-X4 is abundant in the urine of patients with inflammatory kidney diseases and may serve as a biomarker.
- Molecular Weight:
- 1830.2
- Purity:
- >95% by hplc
- References:
- <p>Zirafi et al (2015) Discovery and characterization of an endogenous CXCR4 antagonist. Cell Rep. 11(5) 737<a href="https://pubmed.ncbi.nlm.nih.gov/25921529/" target="_blank" rel="nofollow"> PMID: 25921529</a></p><p>Müller et al (2016) Evaluation of EPI-X4 as a urinary peptide biomarker for diagnosis and prognosis of late acute GvHD. Bone Marrow Transplant. <strong>51</strong>(8) 1137 <a href="https://pubmed.ncbi.nlm.nih.gov/27042833/" target="_blank" rel="nofollow">PMID: 27042833</a><br></p>
- Sequence:
- H-Leu-Val-Arg-Tyr-Thr-Lys-Lys-Val-Pro-Gln-Val-Ser-Thr-Pro-Thr-Leu-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in water
- Formula:
- C84H144N22O23