Chemerin-9
Product Sizes
Chemerin-9
£118.00
CH-010
About this Product
- SKU:
- CH-010
- Additional Names:
- Chemerin 149-157, Chemerin-9 (human), Chemerin C-terminal peptide
- CAS Number:
- 676367-27-4
- Extra Details:
- Chemerin-9 is a nonapeptide corresponding to amino acids 149-157 of the C terminus of processed chemerin, which retains most of the agonist activity of the full-size protein towards the chemokine-like receptor 1 (CMKLR1) with an EC50 of 7.1 nM. Chemerin-9 significantly suppresses TNF-α-induced mRNA expression of adhesion and pro-inflammatory molecules in human umbilical vein endothelial cells (HUVECs) and significantly attenuates TNF-α-induced adhesion of THP1 monocytes and the macrophage inflammatory phenotype. In Apoe -/- mice, a 4-week infusion of chemerin-9 significantly decreases aortic atherosclerotic lesions.
- Molecular Weight:
- 1063.18
- Purity:
- >95% by hplc
- References:
- <p>Wittamer et al (2004) The C-terminal nonapeptide of mature chemerin activates the chemerin receptor with low nanomolar potency. J Biol Chem.<strong> 279</strong>(11) 9956 <a href="https://pubmed.ncbi.nlm.nih.gov/14701797/" target="_blank" rel="nofollow">PMID: 14701797</a></p><p>Sato et al (2019) Chemerin-9, a potent agonist of chemerin receptor (ChemR23), prevents atherogenesis. Clin Sci (Lond). <strong>133</strong>(16) 1779 <a href="https://pubmed.ncbi.nlm.nih.gov/31399499/" target="_blank" rel="nofollow">PMID: 31399499</a></p><p>Kasimu (2020) Regulatory effect of chemerin and therapeutic efficacy of chemerin-9 in pancreatogenic diabetes mellitus. Mol Med Rep.<strong> 21</strong>(3) 981 <a href="https://pubmed.ncbi.nlm.nih.gov/31922216/" target="_blank" rel="nofollow">PMID: 31922216</a><br></p><p><br></p>
- Sequence:
- H-Tyr-Phe-Pro-Gly-Gln-Phe-Ala-Phe-Ser-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C54H66N10O13