AC 187
About this Product
- SKU:
- CG-060
- Additional Names:
- AC 187, 151804-77-2, Ac-VLGKLSQELHKLQTYPRTNTGSNTY-NH2, CG-060, CG060, CG 060
- CAS Number:
- 151804-77-2
- Extra Details:
- AC 187 is an orally active, amylin receptor antagonist with an IC50 of 0.48 nM that displays 38 and 400 fold selectivity over calcitonin and CGRP receptors respectively. Blockade of amylin with AC 187 increases glucagon concentration, accelerates gastric emptying of liquids, and results in an exaggerated post-challenge glycemia. AC 187 alone increases feeding when infused into the area postrema.
- Immunogen:
- Calcitonin and related receptors
- Molecular Weight:
- 2890.25
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Rushing (2001) Inhibition of central amylin signaling increases food intake and body adiposity in rats. Endocrinolog <strong>142</strong>(11) 5035 <a href="https://pubmed.ncbi.nlm.nih.gov/11606473/" target="_blank" rel="nofollow">PMID: 11606473</a><br></p><p>Mollet (2004) Infusion of the amylin antagonist AC 187 into the area postrema increases food intake in rats. Physiol Behav. <strong>81</strong>(1) 149 <a href="https://pubmed.ncbi.nlm.nih.gov/15059694/" target="_blank" rel="nofollow">PMID: 15059694</a></p><p>Gedulin et al (2006) Role of endogenous amylin in glucagon secretion and gastric emptying in rats demonstrated with the selective antagonist, AC187. Regul.Pept. <strong>137</strong> 121 <a href="https://pubmed.ncbi.nlm.nih.gov/16914214/" target="_blank">PMID: 16914214</a></p>
- Sequence:
- Ac-Val-Leu-Gly-Lys-Leu-Ser-Gln-Glu-Leu-His-Lys-Leu-Gln-Thr-Tyr-Pro-Arg-Thr-Asn-Thr-Gly-Ser-Asn-Thr-Tyr-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C127H205N37O40
