Amylin
About this Product
- SKU:
- CG-040
- Additional Names:
- Islet amyloid polypeptide, IAPP
- CAS Number:
- 122384-88-7
- Extra Details:
- Amylin (also known as islet amyloid polypeptide, or IAPP) is a centrally acting, neuroendocrine hormone and member of the calcitonin family of peptides, synthesized and cosecreted with insulin in the beta cells of pancreatic islets. Amylin inhibits glucagon secretion, delays gastric emptying and acts as a satiety agent. Amylin is a major component of the islet amyloid deposited in the pancreas in type 2 diabetes mellitus and may contribute to beta-cell degeneration.
- Molecular Weight:
- 3903.33
- Purity:
- >95% by hplc
- References:
- <p>Castillo et al (1995) Amylin/islet polypeptide: biochemistry, physiology, patho-physiology. Diabete Metab. <strong>21</strong> 3 <a href="https://pubmed.ncbi.nlm.nih.gov/7781840/" target="_blank" rel="nofollow">PMID: 7781840</a></p><p>Schmitz et al (2004) Amylin agonists: a novel approach in the treatment of diabetes. Diabetes. 53 Suppl 3:S233 <a href="https://pubmed.ncbi.nlm.nih.gov/15561917/" target="_blank">PMID: 15561917</a></p><p>Bower and Hay (2016) Amylin structure-function relationships and receptor pharmacology: implications for amylin mimetic drug development. Br J Pharmacol. <strong>173</strong>(12)1883 <a href="https://pubmed.ncbi.nlm.nih.gov/27061187/" target="_blank" rel="nofollow">PMID: 27061187</a><br></p>
- Sequence:
- H-Lys-Cys*-Asn-Thr-Ala-Thr-Cys*-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-His-Ser-Ser-Asn-Asn-Phe-Gly-Ala-Ile-Leu-Ser-Ser-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 (disulfide bridge between cysteines 2 and 7)
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble to 10 mg/ml in DMSO
- Formula:
- C165H261N51O55S2