CGRP (8-37) (rat)
About this Product
- SKU:
- CG-020
- Additional Names:
- CGRP 8-37 (rat), Calcitonin Gene-Related Peptide 8-37 (rat), A Alpha-CGRP (8-37)|CGRP 8-37 (rat), VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2, VTHRLAGLLSRSGGVVKDNFVPTNVGSEAF, 129121-73-9
- CAS Number:
- 129121-73-9
- Extra Details:
- CGRP (8-37) (rat) is a truncated version of calcitonin gene-related peptide (CGRP) that binds to the CGRP receptor with similar affinity and acts as a competitive and highly selective CGRP1 receptor antagonist. CGRP (8-37) (rat) possesses hypothermic and antinociceptive effects and can abolish mechanical and thermal allodynia in chronic central neuropathic pain models.
- Immunogen:
- Calcitonin and related receptors
- Molecular Weight:
- 3127.55
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Poyner (1995) Pharmacology of receptors for calcitonin gene-related peptide and amylin. Trends Pharmacol Sci. <strong>16</strong>(12) 424 doi: 10.1016/s0165-6147(00)89093-8</p><p>Bennett et al (2000) Alleviation of mechanical and thermal allodynia by CGRP(8-37) in a rodent model of chronic central pain. Pain. <strong>86</strong>(1-2) 163 doi: 10.1016/s0304-3959(00)00242-6. PMID: 10779673</p><p>Janzadeh et al (2020) The role of CGRP receptor antagonist (CGRP8-37) and Endomorphin-1 combination therapy on neuropathic pain alleviation and expression of Sigma-1 receptors and antioxidants in rats. J. Chemical Neuroanatomy <strong>106 </strong>101771 https://doi.org/10.1016/j.jchemneu.2020.101771.<br></p>
- Sequence:
- H-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C138H224N42O41
