pFYN peptide
About this Product
- SKU:
- BT-010
- Additional Names:
- pFYN peptide, Biotin-GLARLIEDNE-Y(H2PO3)-TARQGAKFPI-OH, GLARLIEDNEYTARQGAKFPI, phosphorylated, substrate, Src, kinases. AlphaLISA, assay, STEP, FYN, BT-010
- Conjugate:
- Biotin
- Extra Details:
- pFYN peptide is a phosphorylated peptide substrate derived from FYN, a member of the Src family of kinases. pFyn peptide can be used in an AlphaLISA assay for the the identification and optimization of allosteric STEP (striatal-enriched protein tyrosine phosphatase) ligands. STEP is a critical regulator of glutamatergic synapse function and neuronal survival, acting on targets directly involved in regulation of synaptic plasticity such as the NMDA and AMPA receptors, as well as targets regulating these receptors, such as ERK1/2, p38, FYN, and PYK2. pFYN-peptide phosphorylated peptide substrate is used in place of the endogenous STEP substrate FYN.
- Immunogen:
- Kinases
- Molecular Weight:
- 2764.95
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Tautermann et al (2019) Allosteric Activation of Striatal-Enriched Protein Tyrosine Phosphatase (STEP, PTPN5) by a Fragment-like Molecule. J.Med.Chem.<strong> 62</strong> 306
- Sequence:
- Biotin-Gly-Leu-Ala-Arg-Leu-Ile-Glu-Asp-Asn-Glu-Tyr(H2PO3)-Thr-Ala-Arg-Gln-Gly-Ala-Lys-Phe-Pro-Ile-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C115H183N32O43PS
