F9170
About this Product
- SKU:
- AV-010
- Extra Details:
- F9170 is a peptide identified from the cytoplasmic region of the HIV-1 envelope glycoprotein (Env, gp120-gp41) which is able to inactivate HIV-1 virions and induce necrosis of HIV-1 infected cells. F9170 can enter the brain and lymph nodes and specifically targets the conserved cytoplasmic tail of HIV-1 Env to disrupt the integrity of the viral membrane. F9170 short term administration can control viral loads to below the limit of detection in chronically SHIV infected macaques.
- Molecular Weight:
- 1983.3
- Purity:
- >95% by HPLC
- References:
- Wang et al (2020) An amphipathic peptide targeting the gp41 cytoplasmic tail kills HIV-1 virions and infected cells. Sci Transl Med.<strong> 12</strong>(546):eaaz2254 <a href="https://pubmed.ncbi.nlm.nih.gov/32493792/" target="_blank" rel="nofollow">PMID: 32493792</a>
- Sequence:
- H-Gly-Trp-Glu-Ala-Leu-Lys-Tyr-Leu-Trp-Asn-Leu-Leu-Gln-Tyr-Trp-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in water
- Formula:
- C100H135N21O22