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Proteins and Peptides

[Pyr1]-Apelin 13

Product Sizes
1 mg
£83.00
AR-020-1MG
Academic Pricing
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About this Product
SKU:
AR-020
Additional Names:
[Pyr1]-Apelin 13, [pGlu1]-apelin-13|[Pyr1]-Apelin 13, [pGlu1]-apelin-13, pyroglutamyl, endogenous, apelin APJ receptor, 217082-60-5, Glp-RPRLSHKGPMPF-OH, Glp-RPRLSHKGPMPF, AR-020
CAS Number:
217082-60-5
Extra Details:
[Pyr1]-Apelin 13 or [pGlu1]-apelin-13 is a highly potent pyroglutamyl form of apelin 13 which acts as the endogenous ligand for the apelin APJ receptor, with an EC50 of 0.37 nM. [Pyr1]-Apelin 13 is the predominant isoform detected in human heart and plasma and acts as a potent inotropic agent and vasodilator.
Immunogen:
Apelin receptors
Molecular Weight:
1533.8
Physical State:
Freeze dried solid
Purity:
>95%
References:
<p>Tatemoto et al (1998) Isolation and characterization of a novel endogenous peptide ligand for the human APJ receptor. Biochem.Biophys.Res.Comm. <strong>251</strong> 471<a href="https://pubmed.ncbi.nlm.nih.gov/9792798/" target="_blank" rel="nofollow"> PMID: 9792798</a></p><p>Kleinz et al (2005) Emerging roles of apelin in biology and medicine. Pharmacol.Ther. <strong>107</strong> 198 <a href="https://pubmed.ncbi.nlm.nih.gov/15907343/" target="_blank" rel="nofollow">PMID: 15907343</a></p><p>Yang et al (2015) Apelin, Elabela/Toddler, and biased agonists as novel therapeutic agents in the cardiovascular system. TiPS <strong>36</strong>(9) 560 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4577653/" target="_blank" rel="nofollow">PMID: 26143239</a></p><p>Guide to pharmacology -  <a href="https://www.guidetopharmacology.org/GRAC/LigandDisplayForward?ligandId=605" target="_blank" rel="nofollow">[Pyr1]-Apelin 13</a><br></p>
Sequence:
Glp-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH
Shipping Conditions:
Blue Ice
Storage Conditions:
Store dry, frozen and in the dark
Size:
1 mg
Supplier:
Isca Biochemicals
Type:
Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
Solubility:
Soluble in dilute acid and physiological buffers
Formula:
C69H109N22O16S