Hc-CATH
Product Sizes
1 mg
£224.00
AM-380-1MG
About this Product
- SKU:
- AM-380
- Additional Names:
- i>>KFFKRLLKSVRRAVKKFRKKPRLIGLSTLL, AM-380, AM380, Hc-CATH, Sea snake cathelicidin|Sea snake cathelicidin
- Extra Details:
- Hc-CATH is a cathelicidin from the venom of the sea snake Hydrophis cyanocinctus, unusual in being derived from a marine reptile rather than a vertebrate. Hc-CATH possesses potent broad-spectrum antimicrobial activity, acting through disruption of cell membranes and lysis of bacterial cells, while showing low cytotoxicity toward mammalian cells. Hc-CATH also exhibits potent anti-inflammatory activity, in vitro inhibiting LPS-induced production of nitric oxide and pro-inflammatory cytokines, and in vivo significantly reducing the bacterial load and inflammation in mouse models of intraperitoneal and respiratory infection. Hc-CATH confers protection against ZIKV infection and has preventative and therapeutic efficacy in pregnant mice. Hc-CATH decreases the susceptibility of host cells to ZIKV by downregulating expression of AXL, a TAM (TYRO3, AXL and MERTK) family kinase receptor that mediates ZIKV infection, and also directly inactivates ZIKV particles by disrupting the viral membrane.
- Immunogen:
- Antibacterials,Antivirals
- Molecular Weight:
- 3626.33
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- H-Lys-Phe-Phe-Lys-Arg-Leu-Leu-Lys-Ser-Val-Arg-Arg-Ala-Val-Lys-Lys-Phe-Arg-Lys-Lys-Pro-Arg-Leu-Ile-Gly-Leu-Ser-Thr-Leu-Leu-OH
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
