OP-145
Product Sizes
1 mg
£189.00
AM-360-1MG
About this Product
- SKU:
- AM-360
- Additional Names:
- OP 145, OP145, OP-145, Ac-IGKEFKRIVERIKRFLRELVRPLR-NH2, 732984-81-5, P60.4Ac|P60.4Ac
- CAS Number:
- 732984-81-5
- Extra Details:
- OP-145 is a synthetic antimicrobial peptide derived from amino acid sequence 13-36 of human cathelicidin LL-37, further modified to favour the formation of an amphipathic helix. To improve stability against proteolytic degradation, the N-terminus is acetylated and the C-terminus amidated. OP-145 is a potent antibacterial, only lytic to human cells at high concentrations, and shows significant activity against nine methicillin-resistant Staphylococcus aureus (MRSA) strains, reducing their growth and biofilm formation. OP-145 is safe and effective against chronic middle ear infection (otitis media) in humans, and when formulated in poly(lactic-co-glycolic acid) (PLGA) microspheres, OP-145 exerts strong anti-biofilm effects on clinical isolated pathogens and exerts powerful anti-infection effects in vivo.
- Immunogen:
- Antibacterials
- Molecular Weight:
- 3093.77
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- Sequence:
- Ac-Ile-Gly-Lys-Glu-Phe-Lys-Arg-Ile-Val-Glu-Arg-Ile-Lys-Arg-Phe-Leu-Arg-Glu-Leu-Val-Arg-Pro-Leu-Arg-NH2
- Shipping Conditions:
- Blue Ice
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
