AMPR-22
About this Product
- SKU:
- AM-330
- Additional Names:
- AMPR-22, antimicrobial peptide derived from Romo1, AM-330, KKMMKKGGKFGTFMAIGGIR
- Extra Details:
- AMPR-22 is an optimised antimicrobial peptide derived from reactive oxygen species modulator 1 (Romo1), a mitochondrial protein encoded by the nucleus which is a nonselective cation channel in the mitochondrial inner membrane. AMPR-22 shows broad-spectrum antimicrobial activity against 17 sepsis causing bacteria, including multidrug resistant (MDR) strains, by inducing membrane permeabilization. In vivo, AMPR-22 enables a remarkable survival rate in mice injected with MDR bacteria in murine models of sepsis.
- Immunogen:
- Antibacterials
- Molecular Weight:
- 2186.78
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- You et al (2021) A Novel Peptide Derived from the Transmembrane Domain of Romo1 Is a Promising Candidate for Sepsis Treatment and Multidrug-Resistant Bacteria. Int J Mol Sci. <strong>22</strong>(15) 8243<a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8348110/" target="_blank"> PMID: 34361008</a>
- Sequence:
- H-Lys-Lys-Met-Met-Lys-Lys-Gly-Gly-Lys-Phe-Gly-Thr-Phe-Met-Ala-Ile-Gly-Gly-Ile-Arg-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C98H168N28O22S3
