IDR 1002
About this Product
- SKU:
- AM-320
- Additional Names:
- Innate defense regulator peptide 1002
- CAS Number:
- 1224095-25-3
- Extra Details:
- IDR 1002 is a synthetic host defense peptide derivative with strong anti-inflammatory properties which was identified from a library of bactenecin derivatives. IDR 1002 is protective against the Gram-negative bacterial pathogen Escherichia coli with chemokine induction by IDR 1002 being mediated through a Gi-coupled receptor and the PI3K, NF-kappaB, and MAPK signaling pathways. IDR 1002 suppresses in vitro inflammatory responses in murine monocyte/macrophage cells challenged withTLR4 and TLR2 agonists, and reduces airway hyperresponsiveness and inflammation in a house dust mite challenged murine model of airway inflammation.
- Molecular Weight:
- 1652.06
- Purity:
- >95% by hplc
- References:
- <p>Nijnik (2010) Synthetic cationic peptide IDR-1002 provides protection against bacterial infections through chemokine induction and enhanced leukocyte recruitment. J Immunol. <strong>184</strong>(5) 2539 <a href="https://pubmed.ncbi.nlm.nih.gov/20107187/" target="_blank" rel="nofollow">PMID: 20107187</a></p><p>Wu et al (2017) Mechanisms of the Innate Defense Regulator Peptide-1002 Anti-Inflammatory Activity in a Sterile Inflammation Mouse Model. J Immunol. <strong>199</strong>(10) 3592 <a href="https://pubmed.ncbi.nlm.nih.gov/28993516/" target="_blank" rel="nofollow">PMID: 28993516</a></p><p>Piyadasa et al (2021) Disrupting Tryptophan in the Central Hydrophobic Region Selectively Mitigates Immunomodulatory Activities of the Innate Defence Regulator Peptide IDR-1002. J Med Chem. <strong>64</strong>(10) 6696 <a href="https://pubmed.ncbi.nlm.nih.gov/33974425/" target="_blank" rel="nofollow">PMID: 33974425</a><br></p>
- Sequence:
- H-Val-Gln-Arg-Trp-Leu-Ile-Val-Trp-Arg-Ile-Arg-Lys-NH2
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in water
- Formula:
- C79H130N26O13