SAAP 148
About this Product
- SKU:
- AM-300
- Additional Names:
- P148, SAAP-148|SAAP-148, SAAP 148, LKRVWKRVFKLLKRYWRQLKKPVR, Ac-LKRVWKRVFKLLKRYWRQLKKPVR-NH2, AM-300, AM300
- Extra Details:
- SAAP 148 is a synthetic peptide derived from LL-37 which is more stable to plasma proteases and more effective in eradicating bacteria than the parent peptide. In vitro, SAAP (synthetic antimicrobial and antibiofilm peptide) 148 kills MDR pathogens without inducing resistance, prevents biofilm formation, and eliminates established biofilms and persister cells. A single 4-hour treatment with SAAP 148 completely eradicates acute and established biofilm associated infections with methicillin resistant Staphylococcus aureus and MDR Acinetobacter baumannii from wounded ex vivo human skin and murine skin in vivo
- Immunogen:
- Antibacterials
- Molecular Weight:
- 3267.16
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>de Breij et al (2018) The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms. Science Translational Medicine 10 (423) <a href="https://stm.sciencemag.org/content/10/423/eaan4044" target="_blank" rel="nofollow">DOI: 10.1126/scitranslmed.aan4044</a><br></p><p>Scheper et al (2018) SAAP-148 Eradicates MRSA Persisters Within Mature Biofilm Models Simulating Prosthetic Joint Infection. Front Microbiol. <strong>12</strong> 625952 <a href="https://pubmed.ncbi.nlm.nih.gov/33584628/" target="_blank">PMID: 33584628</a></p><p><br></p>
- Sequence:
- Ac-Leu-Lys-Arg-Val-Trp-Lys-Arg-Val-Phe-Lys-Leu-Leu-Lys-Arg-Tyr-Trp-Arg-Gln-Leu-Lys-Lys-Pro-Val-Arg-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C157H261N49O27
