Pap12-6
About this Product
- SKU:
- AM-290
- Additional Names:
- Pap12-6, RWKIFKKVVKKW-NH2, AM290, AM-290
- Extra Details:
- Pap12-6 is an antibacterial peptide derived from the 12 amino acids in the N-terminus of papiliocin, a cecropin found in swallowtail butterfly larvae. Pap12-6 possesses broad-spectrum antibacterial activity, especially against multidrug-resistant Gram-negative bacteria, acting by permeabilizing the bacterial membrane. Pap12-6 significantly reduces the secretion of NO, TNF-A Alpha, and IL-6 and also shows anti-inflammatory activity via a TLR4-mediated NF- K Kappa B signaling pathway. In a mouse sepsis model, Pap12-6 significantly improved survival, reduced bacterial growth in organs, and reduced LPS and inflammatory cytokine levels.
- Immunogen:
- Antibacterials
- Molecular Weight:
- 1645.11
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Kim et al (2019) Development of a novel short 12-meric papiliocin-derived peptide that is effective against Gram-negative sepsis. Sci Rep. <strong>9</strong>(1) 3817 <a href="https://pubmed.ncbi.nlm.nih.gov/30846839/" target="_blank" rel="nofollow">PMID: 30846839</a></p><p>Son et al (2019) Effects of C-Terminal Residues of 12-Mer Peptides on Antibacterial Efficacy and Mechanism. J Microbiol Biotechnol. <strong>29</strong>(11) 1707 <a href="https://pubmed.ncbi.nlm.nih.gov/31546301/" target="_blank">PMID: 31546301</a><br></p>
- Sequence:
- H-Arg-Trp-Lys-Ile-Phe-Lys-Lys-Val-Val-Lys-Lys-Trp-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C83H133N23O12
