BING
About this Product
- SKU:
- AM-280
- Additional Names:
- Blocker of INter-membrane stress responses of Gram-negative bacteria
- Extra Details:
- BING is an antimicrobial peptide found in the plasma of the Japanese rice fish medaka (Oryzias latipes), derived from vacuolar protein sorting-associated protein 13D-like (Vps13D). BING possesses toxicity against a broad range of gram-positive and negative bacteria including drug resistant strains, at concentrations that have low toxicity to mammalian cell lines. BING treatment induces deregulation of periplasmic peptidyl-prolyl isomerases in gram-negative bacteria and also reduces the RNA level of cpxR, an upstream regulator of envelope stress responses which plays a crucial role in the development of antimicrobial resistance.
- Molecular Weight:
- 1464.86
- Purity:
- >95% by hplc
- References:
- Dong et al (2021) BING, a novel antimicrobial peptide isolated from Japanese medaka plasma, targets bacterial envelope stress response by suppressing cpxR expression. Sci Rep. <strong>11</strong>(1) 12219 <a href="https://pubmed.ncbi.nlm.nih.gov/34108601/" target="_blank">PMID: 34108601</a>
- Sequence:
- H-Ile-Arg-Ile-Ile-Leu-Arg-Ala-Gln-Gly-Ala-Leu-Lys-Ile-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in water
- Formula:
- C67H125N21O15