PapRIV
About this Product
- SKU:
- AM-270
- Additional Names:
- PapR-IV|PapRIV, SDLPFEH, PapR-IV
- Extra Details:
- PapRIV is a quorum sensing heptapeptide originating from the Bacillus cereus group, which comprises a number of highly related species. PapRIV possesses in vitro pro-inflammatory effects on microglial BV-2 cell lines and is able to cross the gastro-intestinal tract and the blood-brain barrier. PapRIV shows very high brain influx, suggesting a role in gut-brain signalling.
- Immunogen:
- Antibacterials
- Molecular Weight:
- 843.89
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Grenha et al (2013) Structural basis for the activation mechanism of the PlcR virulence regulator by the quorum-sensing signal peptide PapR. Proc Natl Acad Sci U S A. <strong>110</strong>(3) 1047 <a href="https://pubmed.ncbi.nlm.nih.gov/23277548/" target="_blank" rel="nofollow">PMID: 23277548</a></p><p>Janssens et al (2021) PapRIV, a BV-2 microglial cell activating quorum sensing peptide. Sci Rep. <strong>11</strong>(1) 10723 <a href="https://pubmed.ncbi.nlm.nih.gov/34021199/" target="_blank">PMID: 34021199</a></p>
- Sequence:
- H-Ser-Asp-Leu-Pro-Phe-Glu-His-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in water
- Formula:
- C38H53N9O13
