Mastoparan X
About this Product
- SKU:
- AM-260
- Additional Names:
- Mastoparan X, 72093-22-2, INWKGIAAMAKKLL, INWKGIAAMAKKLL-NH2, AM260, AM-260|MP-X, MPX
- CAS Number:
- 72093-22-2
- Extra Details:
- Mastoparan X is one of the mastoparans that was first isolated from the venom of the Japanese yellow hornet. Mastoparan X shows considerable antimicrobial activity against Gram positive bacteria and can stimulate phospholipase A2 activity as well as being a G protein activator that binds to Gi and Go. Mastoparan X exhibits potent anticancer activity toward human glioblastoma multiforme cells, a process that occurs by membranolytic activity leading to necrosis.
- Immunogen:
- Antibacterials
- Molecular Weight:
- 1556
- Physical State:
- Freeze dried sold
- Purity:
- >95%
- References:
- <p>Sukumar and Higashijima (1992) G protein-bound conformation of mastoparan-X, a receptor-mimetic peptide. J.Biol.Chem. 267 21421 <a href="https://pubmed.ncbi.nlm.nih.gov/1400455/" target="_blank" rel="nofollow">PMID: 1400455</a></p><p>Etzerodt et al (2011) Selective acylation enhances membrane charge sensitivity of the antimicrobial peptide mastoparan-x. Biophys J. <strong>100</strong>(2) 399 <a href="https://pubmed.ncbi.nlm.nih.gov/21244836/" target="_blank" rel="nofollow">PMID: 21244836</a></p><p>da Silva et al (2018) Pro-necrotic Activity of Cationic Mastoparan Peptides in Human Glioblastoma Multiforme Cells Via Membranolytic Action. Mol. Neurobiol. 55, 5490 <a href="https://pubmed.ncbi.nlm.nih.gov/28965321/" target="_blank">PMID: 28965321</a></p><p>UniProt entry - <a href="https://www.uniprot.org/uniprot/P01515" target="_blank">Mastoparan X</a></p>
- Sequence:
- H-Ile-Asn-Trp-Lys-Gly-Ile-Ala-Ala-Met-Ala-Lys-Lys-Leu-Leu-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
