Mastoparan
About this Product
- SKU:
- AM-250
- Additional Names:
- Mastoparan, 72093-21-1, INLKALAALAKKIL-NH2
- CAS Number:
- 72093-21-1
- Extra Details:
- Mastoparan is a peptide toxin from wasp venom with antimicrobial, antiparasitic and anticancer properties. Mastoparan exerts its bactericidal activity by binding to lipid membranes, inducing pores and defects, and leaking the internal contents of vesicles and cells. Mastoparan also shows potent anticancer activity towards leukaemia, myeloma, and breast cancer cells in animal models, also through a lytic mechanism.
- Immunogen:
- Antibacterials,Antiparasitics
- Molecular Weight:
- 1479
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Longland et al (1999) The mechanism of inhibition of the Ca2+-ATPase by mastoparan. J.Biol.Chem. <strong>274</strong> 14799 <a href="https://pubmed.ncbi.nlm.nih.gov/10329678/" target="_blank" rel="nofollow">PMID: 10329678</a></p><p>Dos Santos Cabrera et al (2011) New Insight into the Mechanism of Action of Wasp Mastoparan Peptides: Lytic Activity and Clustering Observed with Giant Vesicles. Langmuir <strong>27</strong>(17) 10805 <a href="https://pubmed.ncbi.nlm.nih.gov/21797216/" target="_blank" rel="nofollow">PMID: 21797216</a></p><p>Hilchie et al (2016) Mastoparan is a membranolytic anti-cancer peptide that works synergistically with gemcitabine in a mouse model of mammary carcinoma. Biochimica et biophysica acta. <strong>1858</strong>(12) 3195 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097029/" target="_blank">PMID: 27693190</a><br></p>
- Sequence:
- H-Ile-Asn-Leu-Lys-Ala-Leu-Ala-Ala-Leu-Ala-Lys-Lys-Ile-Leu-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble to 1 mg/ml in water
- Formula:
- C70H131N19O15
