LAP
About this Product
- SKU:
- AM-190
- Additional Names:
- La peptide|LAP, La peptide, N-terminal La motif, systemic lupus erythematosus, viral internal ribosome entry site, IRES, poliovirus, hepatitis C, IRES-mediated translation, H-AALEAKICHQIEYYFGDF-NH2, AALEAKICHQIEYYFGDF-NH2, AM-190, AM190
- Extra Details:
- LAP (for La peptide) corresponds to amino acids 11 to 28 from the N-terminal oeLa motif of La, a 52-kDa autoantigen found in patients with systemic lupus erythematosus, and one of the first cellular proteins identified to interact with viral internal ribosome entry site (IRES) elements and stimulate poliovirus (PV) and hepatitis C virus (HCV) IRES-mediated translation. LAP efficiently inhibits viral IRES-mediated translation in vitro. LAP does not bind RNA directly but blocks La binding to IRNA and PV 5'-UTR.
- Immunogen:
- Antivirals
- Molecular Weight:
- 2117.41
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- Izumi et al (2004) A Peptide from Autoantigen La Blocks Poliovirus and Hepatitis C Virus Cap-Independent Translation and Reveals a Single Tyrosine Critical for La RNA Binding and Translation Stimulation. J.Virol. <strong>78</strong>(7) 3763 DOI: 10.1128/
- Sequence:
- H-Ala-Ala-Leu-Glu-Ala-Lys-Ile-Cys-His-Gln-Ile-Glu-Tyr-Tyr-Phe-Gly-Asp-Phe-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- We recommend storage desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in DMSO
- Formula:
- C99H141N23O27S
