RW3
About this Product
- SKU:
- AM-150
- Additional Names:
- H-RWRWRW-NH2, RWRWRW-NH2, RW3, RWRWRW, antimicrobial, antifungal, membrane destabilization, pore formation , RW 3, AM-150, AM150
- Extra Details:
- RW3 is a short peptide containing repeating arginine (R) and tryptophan (W) residues which has been shown to possess antimicrobial and antifungal activity with low cytotoxicity. The positively charged arginine interacts with the bacterial membrane through electrostatic attraction whereas the non-polar tryptophan residue interacts with the lipid bilayer. These two properties allow RW3 to interact with the bacterial membrane, resulting in membrane destabilization and pore formation and bacterial cell death. RW3 has been shown to have enhanced activity in combination with other antimicrobial agents.
- Immunogen:
- Antibacterials,Antifungals
- Molecular Weight:
- 1044.2
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Strøm et al (2002) Antimicrobial activity of short arginine- and tryptophan-rich peptides. J. Pept. Sci. <strong>8</strong>(8) 431 doi:10.1002/psc.398 </p><p>Liu et al (2007) Length effects in antimicrobial peptides of the (RW)n series. Antimicrob. Agents Chemother. <strong>51</strong>(2) 597 doi:10.1128/AAC.00828-06 </p><p>Mohan et al (2014) Enhanced antimicrobial activity of peptide-cocktails against common bacterial contaminants of ex vivo stored platelets. Clin. Microbiol. Infect. <strong>20</strong>(1) O39 doi:10.1111/1469-0691.12326</p>
- Sequence:
- H-Arg-Trp-Arg-Trp-Arg-Trp-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid and physiological buffers
- Formula:
- C51H69N19O6
