RsAFP2
Product Sizes
0.1 mg
£306.00
AM-140-0.1MG
About this Product
- SKU:
- AM-140
- Additional Names:
- Raphanus sativus antifungal peptide 2|RsAFP2, raphanus sativus antifungal peptide 2, antifungal, defensin, radish, raphanus sativus, glucosylceramides, membrane permeabilization, fungal cell death, AM-140, AM-140
- Extra Details:
- RsAFP2, or raphanus sativus antifungal peptide 2, is an an antifungal plant defensin isolated from seeds of the radish, raphanus sativus, which interacts with glucosylceramides (GlcCer) in the membranes of susceptible yeast and fungi to induce membrane permeabilization and fungal cell death. RsAFP2 is active against Candida albicans and inhibits to a lesser extent other Candida species, and is nontoxic to mammalian cells. In animal models, RsAFP2 is prophylactically effective against murine candidiasis.
- Immunogen:
- Antifungals,Plant science
- Molecular Weight:
- 5710.6
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Aerts et al (2007) The Antifungal Activity of RsAFP2, a Plant Defensin from Raphanus sativus, Involves the Induction of Reactive Oxygen Species in Candida albicans. J. Mol. Microbiol. Biotechnol. <strong>13</strong> 243doi: 10.1159/000104753 </p><p>Bergter et al (2008) In Vitro Activity of the Antifungal Plant Defensin RsAFP2 against Candida Isolates and Its In Vivo Efficacy in Prophylactic Murine Models of Candidiasis. Antimicrob. Agents Chemother. <strong>52</strong>(12) 4522 DOI: 10.1128/AAC.00448-08 </p><p>Thevissen et al (2012), The plant defensin RsAFP2 induces cell wall stress, septin mislocalization and accumulation of ceramides in Candida albicans. Mol. Microbiol. 84 166 https://doi.org/10.1111/j.1365-2958.2012.08017.x</p>
- Sequence:
- PyroGlu-Lys-Leu-Cys-Gln-Arg-Pro-Ser-Gly-Thr-Trp-Ser-Gly-Val-Cys-Gly-Asn-Asn-Asn-Ala-Cys-Lys-Asn-Gln-Cys-Ile-Arg-Leu-Glu-Lys-Ala-Arg-His-Gly-Ser-Cys-Asn-Tyr-Val-Phe-Pro-Ala-His-Lys-Cys-Ile-Cys-Tyr-Phe-Pro-Cys-OH (disulphide bridges between cysteines 4-51, 15-36, 21-45 and 25-47)
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dark, frozen and desiccated
- Size:
- 0.1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid
- Formula:
- C244H368N76O68S8
