PR 26
About this Product
- SKU:
- AM-111
- Additional Names:
- H-RRRPRPPYLPRPRPPPFFPPRLPPRI-OH, RRRPRPPYLPRPRPPPFFPPRLPPRI, PR 26, cathelicidin host defence, immunomodulatory, PR26, PR-26, AM-111, AM111
- Extra Details:
- PR 26 is the first 26 amino acid residues of the amine terminus of the functional antimicrobial domain of PR 39 (AM-110), the proline-rich cathelicidin host defence and immunomodulatory peptide isolated from porcine polymorphonuclear neutrophils. PR 26 is as least as potent as PR 39 against enteric gram negative bacteria and potentiates neutrophil phagocytosis of Salmonella choleraesuis and decreases the level of S. typhimurium invasion into intestinal epithelial cells, however PR 26 does not lyse cells by pore-forming mechanisms.
- Immunogen:
- Antibacterials
- Molecular Weight:
- 3229.9
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Shi et al (1996) Antibacterial activity of a synthetic peptide (PR-26) derived from PR-39, a proline-arginine-rich neutrophil antimicrobial peptide. Antimicrob. Agents Chemother. <strong>40</strong>(1) 115 doi:10.1128/AAC.40.1.115</p><p>Veldhuizen et al (2014) Antimicrobial and immunomodulatory activities of PR-39 derived peptides. PLoS One <strong>9</strong>(4) e95939 doi:10.1371/journal.pone.0095939</p>
- Sequence:
- H-Arg-Arg-Arg-Pro-Arg-Pro-Pro-Tyr-Leu-Pro-Arg-Pro-Arg-Pro-Pro-Pro-Phe-Phe-Pro-Pro-Arg-Leu-Pro-Pro-Arg-Ile-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store dry, frozen and desiccated
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid
- Formula:
- C153H242N50O28
