PR 39
About this Product
- SKU:
- AM-110
- Additional Names:
- H-RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP-NH2, RRRPRPPYLPRPRPPPFFPPRLPPRIPPGFPPRFPPRFP-NH2, 139637-11-9, PR 39 , cathelicidin, immunomodulatory, wound healing, angiogenesis, PR39, AM-110, AM110
- CAS Number:
- 139637-11-9
- Extra Details:
- PR 39 is a 39 amino acid proline-rich cathelicidin host defence and immunomodulatory peptide isolated from porcine polymorphonuclear neutrophils. PR 39 plays a pivotal role in the innate immune defence of the pig against infections. Besides direct antimicrobial activity, PR 39 is involved in wound healing and also stimulates angiogenesis and inhibits inflammatory responses by selectively blocking proteasome degradation of I K Kappa BA Alpha.
- Immunogen:
- Proteasome,Antibacterials
- Molecular Weight:
- 4719.7
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Li et al (2000) PR39, a peptide regulator of angiogenesis. Nat.Med.<strong> 6</strong> 356 PMID: 10613823 </p><p>Gaczynska et al (2003) Proline and arginine-rich peptides constitute a novel class of allosteric inhibitors of proteasome activity. Biochemistry <strong>42 </strong>8663 PMID: 12873125 </p><p>Veldhuizen et al (2014) Antimicrobial and immunomodulatory activities of PR-39 derived peptides. PLoS One <strong>9</strong>(4) e95939 doi:10.1371/journal.pone.0095939</p>
- Sequence:
- H-Arg-Arg-Arg-Pro-Arg-Pro-Pro-Tyr-Leu-Pro-Arg-Pro-Arg-Pro-Pro-Pro-Phe-Phe-Pro-Pro-Arg-Leu-Pro-Pro-Arg-Ile-Pro-Pro-Gly-Phe-Pro-Pro-Arg-Phe-Pro-Pro-Arg-Phe-Pro-NH2
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid
- Formula:
- C229H346N70O40
