Magainin 1
About this Product
- SKU:
- AM-100
- Additional Names:
- 108433-99-4, H-GIGKFLHSAGKFGKAFVGEIMKS-OH, GIGKFLHSAGKFGKAFVGEIMKS, Magainin 1, amphipathic cationic peptide, antimicrobial, African clawed frog Xenopus laevis, hemolytic, haemolytic, inhibit growth of bacteria by permeabilizing the cell membranes, lipid matrix, membranes, cytotoxic, cancer, AM-100, AM100
- CAS Number:
- 108433-99-4
- Extra Details:
- Magainin 1 is a 23 amino acid amphipathic cationic peptide with broad-spectrum antimicrobial activities, originally extracted from the skin of the African clawed frog Xenopus laevis. Magainin 1 (and Magainin 2) are closely related hemolytic peptides which inhibit growth of bacteria by permeabilizing the cell membranes without significant toxicity against mammalian cells. The main target of magainin 1 and 2 is thought to be the lipid matrix of the membranes. Both magainin 1 and 2 are also cytotoxic to cancer cells and exhibit inhibitory action toward herpes simplex virus 1 and 2 (HSV 1 and 2)
- Immunogen:
- Antibacterials,Antivirals
- Molecular Weight:
- 2409.8
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Zasloff (1987) Magainins, a class of antimicrobial peptides from Xenopus skin: isolation, characterization of two active forms, and partial cDNA sequence of a precursor. Proc. Natl. Acad. Sci. <strong>84</strong>(15) 5449 <a href="https://pubmed.ncbi.nlm.nih.gov/3299384/" target="_blank" rel="nofollow">PMID: 3299384</a></p><p> Nascimento et al (2012) Evaluation of Magainin I interactions with lipid membranes: An optical and electrochemical study. Chem. Phys. Lipids <strong>165</strong>(5) 537 <a href="https://pubmed.ncbi.nlm.nih.gov/22634545/" target="_blank" rel="nofollow">PMID: 22634545</a></p><p>Watanabe and Kawano (2016) Channel Current Analysis for Pore-forming Properties of an Antimicrobial Peptide, Magainin 1, Using the Droplet Contact Method. Anal. Sci. <strong>32</strong>(1) 57 <a href="https://pubmed.ncbi.nlm.nih.gov/26753706/" target="_blank" rel="nofollow">PMID: 26753706</a></p><p><a href="https://pubchem.ncbi.nlm.nih.gov/compound/16132169" target="_blank" rel="nofollow">PubChem - Magainin 1</a></p>
- Sequence:
- H-Gly-Ile-Gly-Lys-Phe-Leu-His-Ser-Ala-Gly-Lys-Phe-Gly-Lys-Ala-Phe-Val-Gly-Glu-Ile-Met-Lys-Ser-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store frozen and desiccated in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid
- Formula:
- C112H177N29O28S
