Histatin 5
Product Sizes
Histatin 5
£176.00
AM-091
About this Product
- SKU:
- AM-091
- CAS Number:
- 104339-66-4
- Extra Details:
- Histatin 5 is a 24 amino acid histidine-rich cationic salivary peptide, formed with histatin 8 from post-translational cleavage of histatin 3. Histatins function as antimicrobial peptides and are important components of the innate immune system. Histatin 5 has broad spectrum antimicrobial action including activity against gram positive and gram negative bacteria, and fungi including Candida albicans and Aspergillus fumigans. Histatin 5 antifungal activity is caused by disruption to mitochondrial respiration through reactive oxygen species (ROS) production.
- Molecular Weight:
- 3036.3
- Purity:
- >95% by HPLC
- References:
- <p>Mochon and Liu (2008) The antimicrobial peptide histatin-5 causes a spatially restricted disruption on the Candida albicans surface, allowing rapid entry of the peptide into the cytoplasm. PLoS Pathog. <strong>4</strong>(10) e1000190 doi:10.1371/journal.ppat.1000190 </p><p>Oudhoff et al (2008) Histatins are the major wound-closure stimulating factors in human saliva as identified in a cell culture assay. FASEB J. <strong>22</strong>(11) 3805 DOI:10.1096/fj.08-112003 </p><p>Hemadi et al (2017) Salivary proteins and microbiota as biomarkers for early childhood caries risk assessment. Int. J. Oral Sci.<strong> 9</strong>, e1 https://doi.org/10.1038/ijos.2017.35</p>
- Sequence:
- H-Asp-Ser-His-Ala-Lys-Arg-His-His-Gly-Tyr-Lys-Arg-Lys-Phe-His-Glu-Lys-His-His-Ser-His-Arg-Gly-Tyr-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store desiccated, frozen and in the dark
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in dilute acid
- Formula:
- C133H195N51O33