BMAP 28 (bovine)
Product Sizes
BMAP 28 (bovine)
£200.00
AM-030
About this Product
- SKU:
- AM-030
- Extra Details:
- BMAP 28 is a 28 amino acid bovine myeloid cathelicidin exhibiting multiple activities against bacteria and fungi. BMAP 28 has an alpha helical structure and this acts to disrupt cell membranes, and can inhibit pan-drug-resistant Acinetobacter baumannii (PDRAB) though interaction with its outer membrane proteins (OMPs). It can also induce membrane permeabilization and death in human tumour cell lines.
- Molecular Weight:
- 3131.9
- Purity:
- >95% by HPLC
- References:
- <p>Risso et al (2002) BMAP-28, an antibiotic peptide of innate immunity, induces cell death through opening of the mitochondrial permeability transition pore. Mol. Cell. Biol. <strong>22(</strong>6) 1926 <a href="https://pubmed.ncbi.nlm.nih.gov/11865069/" target="_blank" rel="nofollow">PMID: 11865069</a></p><p>Brogden et al (2007) Antimicrobial activity of cathelicidins BMAP28, SMAP28, SMAP29, and PMAP23 against Pasteurella multocida is more broad-spectrum than host species specific. Vet. Microbiol. <strong>119</strong> 76 <a href="https://pubmed.ncbi.nlm.nih.gov/16997510/" target="_blank" rel="nofollow">PMID: 16997510</a></p><p>Guo et al (2018) A bovine myeloid antimicrobial peptide (BMAP-28) and its analogs kill pan-drug-resistant Acinetobacter baumannii by interacting with outer membrane protein A (OmpA). Medicine <strong>97</strong>(42), e12832 <a href="https://pubmed.ncbi.nlm.nih.gov/30334982/" target="_blank" rel="nofollow">PMID: 30334982</a></p>
- Sequence:
- H-Gly-Gly-Leu-Arg-Ser-Leu-Gly-Arg-Lys-Ile-Leu-Arg-Ala-Trp-Lys-Lys-Tyr-Gly-Pro-Ile-Ile-Val-Pro-Ile-Ile-Arg-Ile-Gly-OH
- Shipping Conditions:
- Ambient
- Storage Conditions:
- Store dry, frozen and desiccated
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Solubility:
- Soluble in dilute acid
- Formula:
- C147H252N44O31