SMAP 29 (sheep)
About this Product
- SKU:
- AM-020
- Additional Names:
- H-RGLRRLGRKIAHGVKKYGPTVLRIIRIAG-OH, RGLRRLGRKIAHGVKKYGPTVLRIIRIAG, SMAP 29, sheep myeloid antimicrobial peptide, SMAP, cathelicidin, disrupt cell membranes, AM-020, AM020, SMAP-29|Sheep myeloid antimicrobial peptide
- Extra Details:
- SMAP 29 (sheep) is a 29 amino acid sheep myeloid antimicrobial peptide (SMAP) which is a cathelicidin with an alpha helical structure and the ability to disrupt cell membranes. SMAP 29 (sheep) acts as a broad spectrum antimicrobial activity against gram negative and gram-positive bacteria and fungi and has been investigated as a treatment for acute and chronic respiratory infections.
- Immunogen:
- Antibacterials,Antifungals
- Molecular Weight:
- 3256
- Physical State:
- Freeze dried solid
- Purity:
- >95%
- References:
- <p>Kalfa et al (2001) Congeners of SMAP29 Kill Ovine Pathogens and Induce Ultrastructural Damage in Bacterial Cells. Antimicrob. Agents and Chemotherap. <strong>45</strong>(11) 3256 <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC90821/" target="_blank" rel="nofollow">PMID: 11600395</a></p><p>Chang et al (2012) Outer membrane lipoprotein Lpp is Gram-negative bacterial cell surface receptor for cationic antimicrobial peptides. J Biol. Chem. <strong>287</strong>(1) 418 <a href="https://pubmed.ncbi.nlm.nih.gov/22084237/" target="_blank" rel="nofollow">PMID: 22084237</a></p><p>Kao et al (2016) Cathelicidin Antimicrobial Peptides with Reduced Activation of Toll-Like Receptor Signaling Have Potent Bactericidal Activity against Colistin-Resistant Bacteria. mBio <strong>7 </strong>(5) e01418 <a href="https://pubmed.ncbi.nlm.nih.gov/27651360/" target="_blank" rel="nofollow">PMID: 27651360</a></p>
- Sequence:
- H-Arg-Gly-Leu-Arg-Arg-Leu-Gly-Arg-Lys-Ile-Ala-His-Gly-Val-Lys-Lys-Tyr-Gly-Pro-Thr-Val-Leu-Arg-Ile-Ile-Arg-Ile-Ala-Gly-OH
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Store in the dark, frozen and desiccated
- Size:
- 1 mg
- Supplier:
- Isca Biochemicals
- Type:
- Proteins, Peptides, Small Molecules & Other Biomolecules: Peptides
- Solubility:
- Soluble in dilute acid and physiological buffers
- Formula:
- C146H260N52O32
