CD47 monoclonal antibody (B6H12.2), InVivoPure+
Product Sizes
1 mg
£300.00
AK3640PLUS-1MG
5 mg
£600.00
AK3640PLUS-5MG
25 mg
£1800.00
AK3640PLUS-25MG
50 mg
£2900.00
AK3640PLUS-50MG
100 mg
£4200.00
AK3640PLUS-100MG
About this Product
- SKU:
- AK3640PLUS
- Additional Names:
- CD47, Anti CD47, Anti-Human CD47, Anti-Human CD47 (B6H12.2), CD47 monoclonal human antibody(B6H12.2), Clone B6H12.2, HB-9771, IAP clone B6H12.2, InVivo anti-human CD47, Anti-Human mAb CD47, Leukocyte surface antigen CD47, Antigenic surface determinant protein OA3, Integrin-associated protein (IAP), Protein MER6
- Application:
- Block/Inhibit/Neutralise
- Buffer:
- PBS
- translate.label.attr.clone:
- B6H12.2
- Clonality:
- Monoclonal
- Concentration:
- 1 mg/ml
- Extra Details:
- CD47 (also known as Integrin-Associated Protein, IAP) is a ubiquitously expressed transmembrane protein involved in immune evasion by sending a "don't eat me" signal via its interaction with SIRPA Alpha on macrophages. It plays a critical role in tumor immune evasion, self-recognition, and apoptosis regulation. The B6H12.2 antibody is a mouse monoclonal that specifically binds to human CD47. It has been widely cited in both in vitro and in vivo studies, including for blockade of CD47-SIRPA Alpha signaling to enhance phagocytosis of tumor cells. In addition to its primary function, the anti-CD47 mAb blocks the association between CD47, TSP1 (Thrombospondin 1) and integrin A AlphaN NuB Beta3 that promotes vitronectin-associated spreading of melanoma cells. The antibody reacts with vitronectin receptors on human polymorphonuclear leukocytes (PMN, neutrophils) and effectively blocks the receptor binding to the tripeptide Arg-Gly- Asp (RGD). This inhibition extends to RGD-stimulated phagocytosis, demonstrating its functional versatility. Importantly, B6H12.2 does not react with gpIIb/III or the LFA-1/Mac-1 family of cellular adhesion receptors, ensuring targeted specificity. Widely used in immunological assays such as immunohistochemistry and flow cytometry, B6H12.2 is a reliable tool for researchers studying CD47-expressing cells.
- Formulation:
- Clear Liquid, PBS, pH 7.4, 0.2 um sterile filtered
- Host:
- Mouse
- Immunogen:
- nimals were immunized with purified integrin associated protein (IAP, which is physically and functionally associated with vitronectin receptors)
- Isotype:
- IgG1
- Physical State:
- Liquid
- Purity:
- >=95%
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- InVivo Biotech Services GmbH
- Type:
- Antibody: In Vivo Antibodies
