PD-1 monoclonal antibody (RMP1-14), InVivoPure+
Product Sizes
1 mg
£400.00
AK3615PLUS-1MG
5 mg
£600.00
AK3615PLUS-5MG
25 mg
£2100.00
AK3615PLUS-25MG
50 mg
£3600.00
AK3615PLUS-50MG
100 mg
£4100.00
AK3615PLUS-100MG
About this Product
- SKU:
- AK3615PLUS
- Additional Names:
- PD-1, anti-mouse PD1, CD279, programmmed cell death protein 1, Protein PD-1, mPD-1, RMP1-14.
- Application:
- Block/Inhibit/Neutralise
- Buffer:
- PBS
- translate.label.attr.clone:
- RMP1-14
- Clonality:
- Monoclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- PD-1 is expressed on the surface of activated T cells, B cells and myeloid cells. PD-1 has two natural ligands, PD-L1 and PD-L2. Engagement of PD-1 with either ligand suppresses immune responses and promotes self-tolerance. PD-L1 and PD-L2 only share 37% sequence identity, but have similar functions and expression profiles. Where PD-L1 is expressed in immune cells such as T and B cells, DCs, and macrophages, as well as in many different tumor types. PD-L2 expression has been reported to be more restricted to APCs. The overexpression of PD-L1 and/or PD-L2 in cancer cells reduces the body's immune responses, enabling cancer cells to evade killing mediated by T cells. PD-L1 is expressed more widely by tumor cells than PD-L2, and the blockade of the PD-1/PD-L1 interaction is more frequently targeted by therapeutic agents . RMP1-14 is a monoclonal antibody that targets the murine PD-1 protein , and has been used extensively to probe the effects of PD-1 inhibition in preclinical murine models .
- Formulation:
- Clear Liquid, PBS, pH 7.4, 0.2 um sterile filtered
- Host:
- Rat
- Immunogen:
- Mouse PD-1 transfected BHK cells
- Isotype:
- IgG2b, kappa
- Physical State:
- Liquid
- Purity:
- >=95%
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- InVivo Biotech Services GmbH
- Type:
- Antibody: In Vivo Antibodies
- Shipping Costs:
- Free Shipping to the UK
- Main Competitor:
- This product is an equivalent to the main competitor item
