PD-L1 monoclonal antibody (10F.9G2)TM, InVivoPure
Product Sizes
1 mg
£140.00
AK3612P-1MG
5 mg
£450.00
AK3612P-5MG
25 mg
£1750.00
AK3612P-25MG
50 mg
£2600.00
AK3612P-50MG
100 mg
£3500.00
AK3612P-100MG
About this Product
- SKU:
- AK3612P
- Additional Names:
- PD-L1, PD L1 anti-mouse PD-L1, CD274, programmmed cell death ligand 1, PDCD1 Ligand 1, programmmed death ligand 1, B7 homolog 1, B7-H1, 10F9G2, 10F 9G2
- Application:
- Block/Inhibit/Neutralise
- Buffer:
- PBS
- translate.label.attr.clone:
- 10F.9G2TM
- Clonality:
- Monoclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- Programmed death-1 (PD-1) is a cell surface receptor that functions as a T cell checkpoint and plays a central role in regulating T cell exhaustion. Binding of PD-1 to its ligand, programmed death-ligand 1 (PD-L1), activates downstream signaling pathways and inhibits T cell activation. Moreover abnormally high PD-L1 expression on tumor cells and antigen-presenting cells in the tumor microenvironment mediates tumor immune escape, and the development of anti-PD-1/PD-L1 antibodies has recently become a hot topic in cancer immunotherapy. The 10F.9G2 antibody is a monoclonal antibody specific for the mouse protein PD-L1 (Programmed Death Ligand 1), also known as B7-H1 or CD274. PD-L1 is a 40 kDa type I transmembrane protein that belongs to the B7 family of the immunoglobulin superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, as well as on IFN-G Gamma stimulated monocytes, epithelial cells and endothelial cells. The interaction of PD-L1 with its receptor PD-1 on T cells leads to the inhibition of T cell proliferation and cytokine production. The anti-PD-L1 (10F.9G2) blocking antibody blocks interaction of PD-L1 with both of its binding partners, PD-1 and CD80 (B7-1).
- Formulation:
- Clear Liquid, PBS, pH 7.4, 0.2 um sterile filtered
- Host:
- Rat
- Immunogen:
- murine PD-L1-cDNA + CHO-mPD-L1transfectants
- Isotype:
- IgG2b, kappa
- Physical State:
- Liquid
- Purity:
- >=90%
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- InVivo Biotech Services GmbH
- Type:
- Antibody: In Vivo Antibodies
- Shipping Costs:
- Free Shipping to the UK
