HLA-A,B,C monoclonal antibody (W6/32), InVivoPure
Product Sizes
1 mg
£130.00
AK3603P-1MG
5 mg
£400.00
AK3603P-5MG
25 mg
£1600.00
AK3603P-25MG
50 mg
£2400.00
AK3603P-50MG
100 mg
£3500.00
AK3603P-100MG
About this Product
- SKU:
- AK3603P
- Additional Names:
- HLA ABC, anti-HLA Class 1, anti HLA I, Anti-HLA class I
- Application:
- Cell-based/Functional Assay
- Buffer:
- PBS
- translate.label.attr.clone:
- W6/32
- Clonality:
- Monoclonal
- Concentration:
- 0.5 mg/ml
- Extra Details:
- The HLA-A,B,C mAb (W6/32) monoclonal antibody reacts with the human major histocompatibility complex (MHC) class I, HLA-A, B, C. MHC class I antigens associated with beta 2-microglobulin are expressed by all human nucleated cells and are central in cell-mediated immune response and tumor surveillance. W6/32 mAb recognizes a non-polymorphic epitope shared among products of the HLA-A, B, and C loci and immunoprecipitates both 43 kDa and 11-12 kDa chains. Crossreactivity is also seen in baboon, rhesus and cynomolgus monkey. MHC class I plays a crucial role in the adaptive immune response by presenting endogenous antigens to cytotoxic CD8 T cells. The T cell receptor (TCR)/CD3 complex of CD8 T cells interacts with peptide MHC class I, which induces CD8 T cell activation and subsequent cell killing. CD8 molecules also bind to MHC class I, which enhances TCR signaling. In contrast to CD8 T cells, MHC class I is an inhibitory ligand for natural killer cells (NK cells) and promotes self-tolerance.
- Formulation:
- Clear Liquid, PBS, pH 7.4, 0.2 um sterile filtered
- Host:
- Mouse
- Immunogen:
- Animals were immunized with cells from human tonsils. Spleen cells were fused with P3X63Ag8 myeloma cells
- Isotype:
- IgG2a, kappa
- Physical State:
- Liquid
- Purity:
- >=90%
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Storage Conditions:
- Please refer to datasheet
- Supplier:
- InVivo Biotech Services GmbH
- Type:
- Antibody: In Vivo Antibodies
- Shipping Costs:
- Free Shipping to the UK
- Main Competitor:
- This product is an equivalent to the main competitor item
