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Assay Kits & ELISAs

Near-Infrared DyLight[R] 690 Tracer in vivo Active Caspase (VAD) Assay

Product Sizes
20 tests
£527.00
9112-20TESTS
About this Product
SKU:
9112
Application:
Flow Cytometry, Microscopy
CE/IVD:
RUO
Extra Details:
A fluorescent, cell-permeable tracer for the non-invasive measurement of caspase activity in live animals. The Val-Ala-Asp caspase binding sequence gives the DyLight® 690-VAD-FMK Tracer reagent broad caspase reactivity. Dylight® is a registered trademark of Thermo Fisher Scientific, Inc., ICT
Immunogen:
Poly Caspases
Physical State:
Tissue
Purification:
Brain abscesses were induced in mice following the intracerebral inoculation of live Staphylococcus aureus. Animals received intravenous injections of NIR-FLIVO 690 Tracer (kit #9112) or NIR-FLIVO 690
Shipping Conditions:
Blue Ice
Storage Conditions:
-20[o]C
Type:
Assay Kits: Cell Viability
Figure 1. Brain abscesses were induced in mice following inoculation of live S. aureus. Mice received i.v. injections of DyLight® 690-VAD-FMK tracer or DyLight® 690 Dye Control (cat. 9113) 17 hours post-infection; brain tissue was imaged 1 hour later ex vivo using an IVIS® Spectrum™ (Caliper Life Sciences). Strong caspase activity was seen in brain abscesses using DyLight® 690-VAD-FMK tracer (right); minimal signal was detected in the DyLight® 690 Dye Control Free Dye control (left).