Bulk Anti-Human CD2 (LO-CD2a) In Vivo Antibody
Product Sizes
1mg
£149.00
ICH1193-1MG
5mg
£332.00
ICH1193-5MG
25mg
£1057.00
ICH1193-25MG
50mg
£1675.00
ICH1193-50MG
100mg
£2351.00
ICH1193-100MG
About this Product
- SKU:
- ICH1193
- Additional Names:
- BTI-322, CD2, CD2 molecule, T11, SRBC, LFA-2, T-cell surface antigen CD2, LFA-3 receptor, rosette receptor, erythrocyte receptor, lymphocyte-function antigen-2, T-cell surface antigen T11/Leu-5, CD2 antigen (p50), sheep red blood cell receptor
- Application:
- Cell-based/Functional Assay
- CE/IVD:
- RUO
- translate.label.attr.clone:
- LO-CD2a
- Clonality:
- Monoclonal
- Concentration:
- ≥ 2.0 mg/ml
- Extra Details:
- LO-CD2a strongly inhibits mixed lymphocyte culture (MLC) 3 and induces T cell apoptosis. Additionally, LO-CD2a does not induce proliferation of resting T cells, and inhibits T cell proliferation induced by OKT3 antibody, induces very low levels of cytokine release, and also inhibits cytokine production induced by OKT3, LO-CD2a strongly inhibits proliferation of peripheral blood mononuclear cells stimulated with soluble OKT3, and induces human T cell hyporesponsiveness. Adding LO-CD2a to a primary MLC inhibits the T cell proliferation response and has a subsequent inhibitory effect on the secondary immune response, thereby blocking primary and memory alloantigen proliferative responses. The human T cell hyporesponsiveness in the secondary MLC is restricted to alloantigens and occurs both in the absence of antibody and after cell surface re-expression of CD2
- Formulation:
- Sterile, preservative-free, solution in PBS. BSA and Azide free.
- Host:
- Rat
- Immunogen:
- LO-CD2a was developed as an immunosuppressive agent for use in organ allotransplantation. LO-CD2a was produced by immunizing a LOU/C rat with purified human T lymphocytes and fusing the splenocytes with the non-secreting rat fusion cell line IR983F, resulting in a rat IgG2b mAb of the IgK-1a allotype
- Isotype:
- Rat IgG2b Kappa
- Purity:
- >95% by SDS-PAGE
- Purification:
- This monoclonal antibody was purified using Protein G
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- Anti-CD2 antibody (clone LO-CD2a) activity is directed against human CD2.
- Storage Conditions:
- This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- ichorbio
- Type:
- Antibodies:In Vivo Antibodies
- Shipping Costs:
- Free shipping to UK Customers
- Main Competition:
- This product is an equivalent to the major product in the market
- Manufacturer's Data Sheet:https://ichor.bio/productpdf/print/index/url_key/bulk-anti-human-cd2-lo-cd2a-in-vivo-antibody/
