Anti-Mouse Galectin-9 (RG9-1) In Vivo Antibody - Low Endotoxin
Product Sizes
1mg
£149.00
ICH1186-1MG
5mg
£332.00
ICH1186-5MG
25mg
£1057.00
ICH1186-25MG
50mg
£1675.00
ICH1186-50MG
100mg
£2351.00
ICH1186-100MG
About this Product
- SKU:
- ICH1186
- Additional Names:
- Gal-9
- Application:
- Block/Inhibit/Neutralise
- CE/IVD:
- RUO
- translate.label.attr.clone:
- RG9-1
- Clonality:
- Monoclonal
- Concentration:
- ≥ 5.0 mg/ml
- Extra Details:
- Galectin-9 (Gal-9), a member of the galectin family of mammalian lectins, binds β-galactoside. Gal-9 is expressed by many cell types, including endothelial cells, the epithelium of the gastrointestinal tract, T cells, B cells, macrophages, and mast cells. Gal-9 plays a significant role in innate and adaptive immunity and regulates excessive immunity by suppressing interleukin (IL)-17 producing effector T helper cells (Th)17 and Th1 as well as by augmenting Foxp3+ regulatory T cells (Treg). In addition, Gal-9 induces monocytic myeloid-derived suppressor cells (MDSCs), granulocytic MDSCs, and plasmacytoid dendritic cell-like macrophages. Gal-9 also suppresses B cell receptor signaling and is regulated by I-branching of N-glycans. Additionally, Gal-9 stimulates the maturation of dendritic cells. Gal-9 is thought to function by binding to specific carbohydrate moieties in receptor molecules expressed on the surface of its target cells, including the T-cell immunoglobulin- and mucin-domain-containing molecule-3 (Tim-3)1. Gal-9 is predominantly located in the cytoplasm but can also be secreted. Gal-9 is expressed by a variety of tumor cells, plays a role in tumor immunity, and can suppress tumor metastasis by blocking adhesion to endothelium and extracellular matrices. CD45, which regulates antigen receptor signaling, is a major glycoprotein receptor for Gal-9 on naive B cells.
- Formulation:
- This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
- Host:
- Rat
- Immunogen:
- Recombinant mouse galectin-9
- Isotype:
- Rat IgG2b Kappa
- Purity:
- ≥95% monomer by analytical SEC, >95% by SDS Page
- Purification:
- This monoclonal antibody was purified using Protein G
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- RG9-1 activity is directed against mouse galectin-9
- Storage Conditions:
- This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- ichorbio
- Type:
- Antibodies:In Vivo Antibodies
- Shipping Costs:
- Free shipping to UK Customers
- Main Competition:
- This product is an equivalent to the major product in the market
- Manufacturer's Data Sheet:https://ichor.bio/productpdf/print/index/url_key/anti-mouse-galectin-9-rg9-1-in-vivo-antibody-low-endotoxin/
