Anti-Mouse CD27 (RM27-3E5) In Vivo Antibody - Low Endotoxin
Product Sizes
1mg
£149.00
ICH1185-1MG
5mg
£332.00
ICH1185-5MG
25mg
£1057.00
ICH1185-25MG
50mg
£1675.00
ICH1185-50MG
100mg
£2351.00
ICH1185-100MG
About this Product
- SKU:
- ICH1185
- Additional Names:
- CD27L receptor, Tnfrsf7
- Application:
- Cell-based/Functional Assay
- CE/IVD:
- RUO
- translate.label.attr.clone:
- RM27-3E5
- Clonality:
- Monoclonal
- Concentration:
- ≥ 5.0 mg/ml
- Extra Details:
- CD27 is a glycosylated, type I transmembrane protein of the TNFR superfamily that is constitutively expressed on the surface of progenitor and naïve T cells as well as subsets of natural killer (NK) and B cells. CD27 is an immune-checkpoint receptor and ligation with CD70 results in co-stimulatory effects that enhance primary, memory, and recall T cell responses. CD27 signaling has been targeted for the development of viral, autoimmune, and anti-tumor immunotherapies. RM27-3E5 (rat IgG2a) was raised against recombinant mouse CD27-human IgG1 Fc fusion protein and purified from ascites using protein G columns. RM27-3E5 enhances anti-CD3-stimulated T cell proliferation when immobilized in vitro and augments ovalbumin-specific cytotoxic T lymphocyte (CTL) induction when administered in vivo. RM27-3E5 is an agonistic antibody and has been found to support the control of both established lung metastases and subcutaneous tumors. An anti-tumor effect was also observed with RM27-3E5 against EG7/CD27(+) and EG7/CD27(−) tumors, with the effect mediated mainly by T cells with a minor contribution by NK cells. RM27-3E5 exerts its potent anti-tumor effect by inducing a tumor-specific CTL response. RM27-3E5 has potential utility as a non-depleting agonistic anti-CD27 mAb to enhance anti-tumor immunity
- Formulation:
- This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
- Host:
- Rat
- Immunogen:
- Mouse CD27-human IgG1 Fc fusion protein
- Isotype:
- Rat IgG1 Kappa
- Purity:
- ≥95% monomer by analytical SEC, >95% by SDS Page
- Purification:
- This monoclonal antibody was purified using Protein G
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- RM27-3E5 activity is directed against mouse CD27
- Storage Conditions:
- This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- ichorbio
- Type:
- Antibodies:In Vivo Antibodies
- Shipping Costs:
- Free shipping to UK Customers
- Main Competition:
- This product is an equivalent to the major product in the market
- Manufacturer's Data Sheet:https://ichor.bio/productpdf/print/index/url_key/anti-mouse-cd27-rm27-3e5-in-vivo-antibody-low-endotoxin/
