Anti-Mouse Fas Ligand (MFL3) In Vivo Antibody - Low Endotoxin
Product Sizes
5 mg
ICH1178-5MG
25 mg
ICH1178-25MG
50 mg
ICH1178-50MG
100 mg
ICH1178-100MG
About this Product
- SKU:
- ICH1178
- Additional Names:
- FasL, Apo-1 Ligand, CD95 Ligand, TNFSF6, CD178
- Application:
- Block/Inhibit/Neutralise, Flow Cytometry, Immunofluorescence
- CE/IVD:
- RUO
- translate.label.attr.clone:
- MFL3
- Clonality:
- Monoclonal
- Concentration:
- ≥ 5.0 mg/ml
- Extra Details:
- FasL antibody, clone AFS98, recognizes Fas ligand (FasL), also known as CD178, Apo-1 ligand, and CD95 ligand. FasL is a 40 kDa type II integral membrane protein that belongs to the tumor necrosis factor (TNF) superfamily. FasL is expressed by activated T cells and natural killer (NK cells). Binding of FasL to its receptor Fas (CD95, APO-1) induces apoptotic cell death in Fas-expressing target cells, contributing to anti-viral immunity. FasL also contributes to peripheral tolerance and the downregulation of immune responses through activation-induced autocrine and paracrine T cell death. FasL is also found in the anterior chamber of the eye and on Sertoli cells in the testis, and is implicated in immune-privilege at these sites. FasL also contributes to CD8 proliferation and neutrophil recruitment. Soluble FasL (26 kDa) can be released following cleavage by metalloproteinases and block FasL-mediated signaling. Fas/FasL-signaling is involved in the development of many human diseases, including autoimmunity and cancer. Many human tumors over-express FasL, resulting in tumor infiltrating lymphocyte (TIL) apoptosis and immune evasion, which is associated with poor prognosis.
- Formulation:
- This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (150 mM NaCl) PBS pH 7.2 - 7.4 with no carrier protein, potassium, calcium or preservatives added.
- Host:
- Hamster
- Immunogen:
- B6 mouse FasL cDNA-transfected baby hamster kidney (B6 FasL/BHK) cells
- Isotype:
- IgG
- Purity:
- ≥95%
- Purification:
- This monoclonal antibody was purified using Protein A
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- Clone MFL3 recognizes an epitope on mouse FasL
- Storage Conditions:
- 2-8[o]C Aliquot. Avoid freeze/thaw cycles.
- Supplier:
- ichorbio
- Type:
- Antibody: Monoclonal Antibody
- Shipping Costs:
- Free shipping to UK Customers
- Main Competition:
- This product is an equivalent to the major product in the market
- Manufacturer's Data Sheet:https://ichor.bio/productpdf/print/index/url_key/anti-mouse-fas-ligand-mfl3-in-vivo-antibody-low-endotoxin/
