Bulk Anti-Human CD40 (G28.5) Antibody - Ultra-Low Endotoxin
Product Sizes
5mg
£429.00
ICH1156UL-5MG
25mg
£1428.00
ICH1156UL-25MG
50mg
£2104.00
ICH1156UL-50MG
100mg
£3012.00
ICH1156UL-100MG
About this Product
- SKU:
- ICH1156UL
- Additional Names:
- Tumor necrosis factor receptor superfamily member 5, BP50, CD40L receptor
- Application:
- Cell-based/Functional Assay
- CE/IVD:
- RUO
- translate.label.attr.clone:
- G28.5
- Clonality:
- Monoclonal
- Concentration:
- 1.0 – 5.0 mg/ml
- Extra Details:
- CD40 is a 48 kD type I transmembrane glycoprotein that is a member of the TNFR superfamily. CD40, in association with its ligand CD154 (CD40L) - a 39 kD protein, acts as a costimulatory molecule for the activation of B cells, dendritic cells, monocytes, and other antigen presenting cells. CD40 is involved in Ig isotype switching and dendritic cell maturation, as well as the activation, differentiation and proliferation of B cells. CD40 interacts with TNFR2 and is involved in the regulation of signal transduction. CD40 is a potential target for cancer immunotherapy. Blocking the interaction of CD40 with its ligand (CD154) is the sought-after therapeutic objective for preventing and/or improving both autoimmune diseases and transplant rejection. Studies have shown that monoclonal antibodies that block CD154 in human clinical trials resulted in unanticipated vascular complications. Hence, an interest in the therapeutic potential for antagonist mAbs specific for human CD40 is emerging. Antibodies of particular therapeutic interest are those that do not inhibit CD40 signaling via physical competition with CD154. Additionally, the interaction of CD40 and its ligand (CD154) is found to be essential for amyloid-beta-induced microglial activation, thus plays a significant part in Alzheimer disease pathogenesis.
- Formulation:
- This monoclonal antibody is aseptically packaged and formulated in 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added. BSA and a
- Host:
- Mouse
- Immunogen:
- CD40
- Isotype:
- Mouse IgG1 Kappa
- Purity:
- >98% by SDS-PAGE and HPLC
- Purification:
- This monoclonal antibody was purified using Protein A
- Reactivities:
- Human
- Shipping Conditions:
- Blue Ice
- Specificity:
- Clone G28.5 recognizes an epitope on human CD40
- Storage Conditions:
- This antibody is stable for at least one week when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- ichorbio
- Type:
- Antibodies
- Shipping Costs:
- Free shipping to UK Customers
