Anti-CD278 (7E.17G9) In Vivo Antibody - Low Endotoxin
Product Sizes
1mg
£131.00
ICH1082-1MG
5mg
£332.00
ICH1082-5MG
25mg
£1057.00
ICH1082-25MG
50mg
£1675.00
ICH1082-50MG
100mg
£2351.00
ICH1082-100MG
About this Product
- SKU:
- ICH1082
- Additional Names:
- Inducible T-cell costimulator, Icos, Activation-inducible lymphocyte immunomediatory molecule, CD28 and CTLA-4-like protein, CCLP, CD28-related protein 1, CRP-1, Ailim, CD278
- Application:
- Block/Inhibit/Neutralise
- CE/IVD:
- RUO
- translate.label.attr.clone:
- 7E.17G9
- Clonality:
- Monoclonal
- Concentration:
- 1.0 - 5.0 mg/ml
- Extra Details:
- Inducible co-stimulator (ICOS), also called ALIM and H4, is a homodimeric protein and member of the CD28 family of immune co-stimulatory receptors. Other family members are CD28, CTLA-4 and PD-1. ICOS enhances all basic T cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B cells. Unlike the constitutively expressed CD28, ICOS has to be de novo induced on the T cell surface, does not up-regulate the production of IL-2, but superinduces the synthesis of IL-10, a B cell-differentiation factor. In vivo, ICOS is highly expressed on tonsillar T cells, which are closely associated with B cells in the apical light zone of germinal centres, the site of terminal B cell maturation. ICOS regulates CD28-dependent and CD28-independent CD4 (+) subset (Th1 and Th2) responses. It is a major regulator of the adaptive immune system and therefore, has a protective role in inflammatory autoimmune diseases.
- Formulation:
- 0.01 M phosphate buffered saline (PBS) pH 7.2, 150 mM NaCl with no carrier protein, potassium or preservatives added.
- Host:
- Rat
- Immunogen:
- ICOS
- Isotype:
- Rat IgG2b
- Purity:
- >95% by SDS-PAGE and HPLC
- Purification:
- This monoclonal antibody was purified using Protein G
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- Anti-CD278 In Vivo Antibody - Low Endotoxin (7E.17G9) recognizes an epitope on Mouse ICOS
- Storage Conditions:
- anti-CD278 In Vivo Antibody - Low Endotoxin (7E.17G9) is stable when stored at 2-8°C. Do not freeze. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- ichorbio
- Type:
- Antibodies:In Vivo Antibodies
- Shipping Costs:
- Free shipping to UK Customers
- Main Competition:
- This product is an equivalent to the major product in the market
- Manufacturer's Data Sheet:https://ichor.bio/productpdf/print/index/url_key/anti-cd278-7e-17g9-in-vivo-antibody-low-endotoxin/
