Anti-Mouse CD40 (FGK4.5) In Vivo Antibody - Ultra-Low Endotoxin
Product Sizes
5mg
£429.00
ICH1073UL-5MG
25mg
£1428.00
ICH1073UL-25MG
50mg
£2104.00
ICH1073UL-50MG
100mg
£3012.00
ICH1073UL-100MG
About this Product
- SKU:
- ICH1073UL
- Application:
- Cell-based/Functional Assay
- CE/IVD:
- RUO
- translate.label.attr.clone:
- FGK4.5
- Clonality:
- Monoclonal
- Concentration:
- > 2.0 mg/ml
- Extra Details:
- CD40, also known as TNFSF5, is a type I transmembrane protein and member of the TNF receptor family. The binding of CD40L (CD154) on TH cells to CD40 activates antigen presenting cells and induces a variety of downstream effects. CD40 is expressed on B cells, dendritic cells, monocytes, thymic epithelial cells and, at low levels, on T cells. Signaling though CD40 plays an important role in the proliferation and differentiation of B cells and is critical for immunoglobulin (Ig) class switching. The membrane-anchored CD40L is expressed almost exclusively on activated CD4+ T lymphocytes. Failure to express CD40L leads to "immunodeficiency with hyper-IgM", a disease characterized by failure to produce IgG, IgA and IgE. Some of the early intracellular signaling by the CD4-CD40L system includes the association of the CD40 with TRAFs and the activation of various kinases (4). Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of CD4-CD40L is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis.
- Formulation:
- 0.01 M phosphate buffered saline (PBS) pH 7.2 - 7.4, 150 mM NaCl with no carrier protein, potassium or preservatives added.
- Host:
- Rat
- Immunogen:
- Recombinant Mouse CD40 Fusion Protein
- Isotype:
- Rat IgG2a
- Purity:
- >98% by SDS-PAGE and HPLC
- Purification:
- This monoclonal antibody was purified using Protein G
- Reactivities:
- Mouse
- Shipping Conditions:
- Blue Ice
- Specificity:
- Anti-CD40 In Vivo Antibody - Ultra Low Endotoxin (FGK4.5) recognizes an epitope on Mouse CD40
- Storage Conditions:
- anti-CD40 In Vivo Antibody - Ultra Low Endotoxin (FGK4.5) is stable for at least four (4) weeks when stored sterile at 2-8°C. For long term storage aseptically aliquot in working volumes without diluting and store at –80°C. Avoid Repeated Freeze Thaw Cycles.
- Supplier:
- ichorbio
- Type:
- Antibodies:In Vivo Antibodies
- Shipping Costs:
- Free shipping to UK Customers
- Manufacturer's Data Sheet:https://ichor.bio/productpdf/print/index/url_key/anti-mouse-cd40-fgk4-5-in-vivo-antibody-low-endotoxin/
